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  4. Recombinant Rat Nuclear receptor subfamily 0 group B member 1 (Nr0b1)

Recombinant Rat Nuclear receptor subfamily 0 group B member 1 (Nr0b1)

  • 中文名称：
    大鼠Nr0b1重组蛋白
  • 货号：
    CSB-YP016041RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nr0b1重组蛋白
  • 货号：
    CSB-EP016041RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nr0b1重组蛋白
  • 货号：
    CSB-EP016041RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nr0b1重组蛋白
  • 货号：
    CSB-BP016041RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nr0b1重组蛋白
  • 货号：
    CSB-MP016041RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nr0b1
  • Uniprot No.：
  • 别名：
    Nr0b1; Ahch; Dax1; Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-472
  • 氨基酸序列
    MAGEDHPWHG SILYNLLMSA KQKHGSREER EVRLGAQCWG CACGTQPVLG GEGLPGGQAL SLLYRCCFCG ENHPRQGGIL YSMLTNARQP SGATEAPRAR FRTPCWGCAC SNAKPLVGRX GLPAGQVPSL LYRCCFCGKK HPRQGSILYS LLTNAQQTHV SREVPEAHRG GEWWQLSYCT HNVGGPEGLQ STQAMAFLYR SYVCCEEQPQ QSSVASDTPV RADQTPAAPQ EQPRAPWWDT SSGVQRPIAL KDPQVVCEAA SAGLLKTLRF VKYLPCFQIL PLDQQLVLVR SCWAPLLMLE LAQDHLHFEM MEISEPNLMH EMLTTRRQET EGPEPADPQA TEQPQTVSAE AGHVLSVAAV QAIKSFFFKC WSLNIDTKEY AYLKGTVLFN PDLPGLQCVK YIESLQWRTQ QILTEHIRLM QREYQIRSAE LNSALFLLRF INTDVVTELF FRPIIGAVSM DDMMLEMLCA KL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.
  • 基因功能参考文献：
    1. In conclusion, the presented data revealed that the pituitary Nr5a1/Ctnnb1/Nr0b1 system is controlled by endogenous Gnrh network activity, and hypothalamic-derived regulatory inputs can affect the processes responsible for gene transcription, translation, and protein intracellular translocation. PMID: 30342431
    2. High fat diet aggravates BDE47-inhibited testosterone production through hyperinsulinemia, and the accumulation of testicular BDE47 that induces the up-regulation of DAX-1 and the subsequent down-regulation of steroidogenic proteins. PMID: 28300557
    3. In vivo blockade of testicular alpha1-adrenergic receptors changed the stress-induced decrease of Nur77 and increase of Arr19 and Dax1 in Leydig cells. PMID: 26003139
    4. These results suggest that the low level of DAX-1 may enhance the transcriptional activity of SF-1 and expression of genes related to glucocorticoid synthesis, which are targeted by SF-1, in adrenals from SHR. PMID: 22447829
    5. DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis PMID: 20080977
    6. Nr0b1 negatively regulates steroid synthesis through the inhibition of StAR expression and indicate that the absence of Nr0b1 in R2C cells is, at least in part, responsible for the constitutive steroidogenesis and StAR expression observed. PMID: 15358680
    7. Dexamethasone increases expression of DAX-1, which results in increased amounts of complexed DAX-1-SF-1, in the absence of any change in the expression of SF-1. PMID: 17526944

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR0 subfamily
  • 数据库链接：

    KEGG: rno:58850

    STRING: 10116.ENSRNOP00000005023

    UniGene: Rn.10596