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  4. Recombinant Rat Cell growth-regulating nucleolar protein (Lyar)

Recombinant Rat Cell growth-regulating nucleolar protein (Lyar)

  • 中文名称：
    大鼠Lyar重组蛋白
  • 货号：
    CSB-YP721477RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Lyar重组蛋白
  • 货号：
    CSB-EP721477RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Lyar重组蛋白
  • 货号：
    CSB-EP721477RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Lyar重组蛋白
  • 货号：
    CSB-BP721477RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Lyar重组蛋白
  • 货号：
    CSB-MP721477RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lyar
  • Uniprot No.：
  • 别名：
    LyarCell growth-regulating nucleolar protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-386
  • 氨基酸序列
    MVFFTCNACG ESVKKIQVEK HVSICRNCEC LSCIDCGKDF WGDDYKNHVK CISEDQKYGG KGYEAKTHKG DVKQQAWIQK INELIKKPNV SPKVRELLQQ ISAFDNVPRK KAKFQNWMRN SLKVHSDSVL EQVWNIFSEA ASSEQDQQPP SHMAKPNTEV PTKVPSTKTN GTTEEQTEAK KNKRERKEER QKSRKKEKKE LKLENHQENL KGQKPKKRKK GQEAGHEAGG EDAAEANGAP EKKRARDAQA SEEGADRNGG PAEDADEGPT KTAAGKRKRQ KHSEVESDNK KKKMKLPGQP EEGEPEDHEA PSKGKFNWKG TIKAVLKQAP DNEISVKKLK KKVIAQYHAV MSDHHTSEEE LLAIFNKKIS RNPTFKVLKD KVKLLK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter. Represses the expression of embryonic globin Hbb-y gene. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal.
  • 亚细胞定位：
    Nucleus, nucleolus. Cytoplasm. Cell projection, cilium, photoreceptor outer segment.
  • 组织特异性：
    Expressed in testis (at protein level).
  • 数据库链接：

    KEGG: rno:289707

    STRING: 10116.ENSRNOP00000007154

    UniGene: Rn.137862