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  4. Recombinant Human Histone deacetylase 11 (HDAC11)

Recombinant Human Histone deacetylase 11 (HDAC11)

  • 中文名称：
    人HDAC11重组蛋白
  • 货号：
    CSB-YP010237HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HDAC11重组蛋白
  • 货号：
    CSB-EP010237HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HDAC11重组蛋白
  • 货号：
    CSB-BP010237HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HDAC11重组蛋白
  • 货号：
    CSB-MP010237HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HDAC11
  • Uniprot No.：
  • 别名：
    FLJ22237; HD 11; HD11; HDA11_HUMAN; HDAC 11; HDAC11; Histone deacetylase 11
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-347
  • 氨基酸序列
    MLHTTQLYQH VPETRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDSML VEAREASEED LLVVHTRRYL NELKWSFAVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL DAHQGNGHER DFMDDKRVYI MDVYNRHIYP GDRFAKQAIR RKVELEWGTE DDEYLDKVER NIKKSLQEHL PDVVVYNAGT DILEGDRLGG LSISPAGIVK RDELVFRMVR GRRVPILMVT SGGYQKRTAR IIADSILNLF GLGLIGPESP SVSAQNSDTP LLPPAVP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
  • 基因功能参考文献：
    1. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts. PMID: 29655790
    2. Mycobacterium tuberculosis infection disturbs the HDAC6/HDAC11 levels to induce IL-10 expression in macrophages. PMID: 29523311
    3. HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10. Hence, antagonizing HDAC11 activity may have anti-tumor potential, whereas activating HDAC11 may be useful to treat chronic inflammation or autoimmunity. PMID: 29222071
    4. Results showed that the high levels of HDAC11 and lower levels of p53 were detected in pituitary tumor cells. A negative correlation was detected between the data of HDAC11 and p53. PMID: 28782861
    5. Our study identified a group of cell cycle-promoting genes regulated by HDAC11. PMID: 28252645
    6. High HDAC11 expression is associated with neoplasms. PMID: 23024001
    7. Data indicate a pronounced deregulation of HDAC genes HDAC9 and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). PMID: 21806350
    8. These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression. PMID: 21239696
    9. HDAC11 associates with replication origins inhibits Cdt1-induced re-replication and suppresses MCM loading. PMID: 20980834
    10. We found a reduction of HDAC 11 mRNA and increased HDAC 2 levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls. PMID: 20467334
    11. cloning and functional characterization PMID: 11948178
    12. Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer. PMID: 16142391
    13. the absence of tumour-specific somatic events in WNT7A and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours PMID: 17201809
    14. HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells. PMID: 19011628
    15. Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11 PMID: 19276081

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  • 亚细胞定位：
    Nucleus. Note=Predominantly nuclear.
  • 蛋白家族：
    Histone deacetylase family
  • 组织特异性：
    Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
  • 数据库链接：

    HGNC: 19086

    OMIM: 607226

    KEGG: hsa:79885

    STRING: 9606.ENSP00000295757

    UniGene: Hs.744132