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TNRC6B Antibody

  • 货号：
    CSB-PA892489LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA892489LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNRC6B Polyclonal antibody
  • Uniprot No.：
    Q9UPQ9
  • 基因名：
    TNRC6B
  • 别名：
    TNRC6B antibody; KIAA1093 antibody; Trinucleotide repeat-containing gene 6B protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Trinucleotide repeat-containing gene 6B protein (639-779AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNRC6B Antibody (CSB-PA892489LA01HU)，的标记方式是Non-conjugated。对于TNRC6B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892489LB01HU TNRC6B Antibody, HRP conjugated ELISA
    FITC CSB-PA892489LC01HU TNRC6B Antibody, FITC conjugated
    Biotin CSB-PA892489LD01HU TNRC6B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
  • 基因功能参考文献：
    1. The rs12484776 significantly contributes to uterine myoma risk among Saudi women, both in single and also in synergistic cooperation with rs2280543, rs7913069, and rs1056836 markers. PMID: 27987337
    2. single nucleotide polymorphisms in the TNRC6B gene is associated with uterine fibroid. PMID: 23604678
    3. Trinucleotide repeat containing 6B (TNRC6B) rs12484776 associated with uterine fibroid volume in european americans. PMID: 23892540
    4. Our findings indicate that TNRC6B, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768
  • 亚细胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    GW182 family
  • 数据库链接：

    HGNC: 29190

    OMIM: 610740

    KEGG: hsa:23112

    STRING: 9606.ENSP00000401946

    UniGene: Hs.372082