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SLC38A9 Antibody

  • 中文名称：
    SLC38A9兔多克隆抗体
  • 货号：
    CSB-PA836713LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate
      All lanes: SLC38A9 antibody at 3.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 64, 53, 57 kDa
      Observed band size: 64 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA836713LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA836713LA01HU at dilution of 1:100
    • Immunofluorescent analysis of U251 cells using CSB-PA836713LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC38A9 Polyclonal antibody
  • Uniprot No.：
    Q8NBW4
  • 基因名：
  • 别名：
    FLJ46104 antibody; FLJ90709 antibody; Homo sapiens solute carrier family 38; member 9 antibody; MGC120544 antibody; OTTHUMP00000161835 antibody; Putative sodium coupled neutral amino acid transporter 9 antibody; Putative sodium-coupled neutral amino acid transporter 9 antibody; Putative uncharacterized protein FLJ90709 antibody; S38A9_HUMAN antibody; SLC38A9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sodium-coupled neutral amino acid transporter 9 protein (1-119AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC38A9 Antibody (CSB-PA836713LA01HU)，的标记方式是Non-conjugated。对于SLC38A9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836713LB01HU SLC38A9 Antibody, HRP conjugated ELISA
    FITC CSB-PA836713LC01HU SLC38A9 Antibody, FITC conjugated
    Biotin CSB-PA836713LD01HU SLC38A9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation.
  • 基因功能参考文献：
    1. Ragulator and SLC38A9 act on the Rag GTPases to activate the mTORC1 pathway in response to nutrient sufficiency. PMID: 30181260
    2. Study validates that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins. PMID: 29053970
    3. Data suggest that amino acid transporter SLC38A9 controls mTORC1 activity through binding to the Rag-Ragulator complex at the lysosome upon amino acid availability. PMID: 25963655
    4. SLC38A9 is a physical and functional component of the amino acid sensing machinery that controls the activation of mTOR PMID: 25561175
    5. SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the mTORC1 pathway. PMID: 25567906
    6. SNPs within SLC38A9 are correlated with inflammatory bowel disease patients' 6-thioguanine nucleotide blood concentrations. PMID: 24762746

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  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid/polyamine transporter 2 family, SLC38A9 subfamily
  • 数据库链接：

    HGNC: 26907

    OMIM: 616203

    KEGG: hsa:153129

    STRING: 9606.ENSP00000316596

    UniGene: Hs.742101