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PHLDB2 Antibody

  • 货号：
    CSB-PA803110LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue
      All lanes: PHLDB2 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 143, 137, 140 kDa
      Observed band size: 143, 96 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA803110LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA803110LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA803110LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PHLDB2 Polyclonal antibody
  • Uniprot No.：
    Q86SQ0
  • 基因名：
    PHLDB2
  • 别名：
    LL5 beta antibody; LL5B antibody; LL5beta antibody; PHLB2_HUMAN antibody; PHLDB2 antibody; Pleckstrin homology-like domain family B member 2 antibody; Protein LL5-beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Pleckstrin homology-like domain family B member 2 protein (734-1030AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PHLDB2 Antibody (CSB-PA803110LA01HU)，的标记方式是Non-conjugated。对于PHLDB2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA803110LB01HU PHLDB2 Antibody, HRP conjugated ELISA
    FITC CSB-PA803110LC01HU PHLDB2 Antibody, FITC conjugated
    Biotin CSB-PA803110LD01HU PHLDB2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane.
  • 基因功能参考文献：
    1. Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions. PMID: 27378169
    2. Collectively, our findings present the first to elucidate that miR-29c is a direct p53 target gene, and also identify PHLDB2 as an important miR-29c target gene involved in colon cancer metastasis. PMID: 28392396
    3. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge PMID: 24982445
    4. These and other LL5beta-interacting proteins are associated with conventional podosomes in macrophages and podosome-like invadopodia in fibroblasts, strengthening the close relationship between synaptic and non-synaptic podosomes. PMID: 23525008
    5. minor allele, A, intronic single nucleotide polymorphism 'rs951660'in PHLDB2 might induce a delayed splicing and increase the susceptibility to Vascular dementia PMID: 22111664
    6. Signaling from laminin-integrin associations in epithelial cells attaches microtubule plus ends to the epithelial basal cell cortex via PHLDB1 and PHLDB2. PMID: 20513769
    7. LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2. PMID: 20236936
    8. LL5beta and ELKS can form a PIP3-regulated cortical platform to which CLASPs attach distal microtubule ends. PMID: 16824950

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.
  • 数据库链接：

    HGNC: 29573

    OMIM: 610298

    KEGG: hsa:90102

    STRING: 9606.ENSP00000377502

    UniGene: Hs.603252