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PCGF2 Antibody

  • 中文名称：
    PCGF2兔多克隆抗体
  • 货号：
    CSB-PA017606LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of A549 cells using CSB-PA017606LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PCGF2 Polyclonal antibody
  • Uniprot No.：
    P35227
  • 基因名：
  • 别名：
    DNA binding protein Mel 18 antibody; DNA-binding protein Mel-18 antibody; Mel 18 antibody; MGC10545 antibody; PCGF 2 antibody; PCGF2 antibody; PCGF2_HUMAN antibody; Polycomb group ring finger 2 antibody; Polycomb group RING finger protein 2 antibody; RING finger protein 110 antibody; RNF110 antibody; Zinc finger protein 144 antibody; ZNF 144 antibody; ZNF144 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Polycomb group RING finger protein 2 protein (103-316AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PCGF2 Antibody (CSB-PA017606LA01HU)，的标记方式是Non-conjugated。对于PCGF2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017606LB01HU PCGF2 Antibody, HRP conjugated ELISA
    FITC CSB-PA017606LC01HU PCGF2 Antibody, FITC conjugated
    Biotin CSB-PA017606LD01HU PCGF2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
  • 基因功能参考文献：
    1. Low expression of Mel-18 is correlated with gastric cancer. PMID: 27542229
    2. Mel-18 underexpression in luminal breast cancer cells caused ER-alpha downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 transactivators p53 and SP1. PMID: 25822021
    3. It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression. PMID: 24964959
    4. Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer. PMID: 23474752
    5. PCGF2, a PRC1 gene, played a negative role in the granulocytic differentiation of human APL cells. PMID: 22085718
    6. these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer. PMID: 21602890
    7. Loss of Mel-18 is associated with prostate cancer. PMID: 19395284
    8. Our analysis showed correlation between BMI1 and PCGF2 gene's expression and survival in children with medulloblastoma. PMID: 20717685
    9. Bmi-1/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy. PMID: 21162745
    10. Mel-18 may serve as a useful marker in prognostic evaluation for patients with breast cancer. PMID: 20444850
    11. Decreased Mel-18 and increased Bmi-1 mRNA expression was associated with the carcinogenesis and progression of gastric cancer PMID: 21059209
    12. An association of Mel18 with emerin was observed in Hutchinson-Gilford progeria syndrome, but not in WT cells. PMID: 19727227
    13. Mel-18 plays a significant role in the angiogenic function of endothelial cells by regulating endothelial gene expression. PMID: 20801102
    14. BMI1 acts as an oncogene and Mel-18 functions as a tumor suppressor via downregulation of BMI1. PMID: 20170541
    15. The oncogenic role of MEL-18 in human primary breast carcinomas is determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity. PMID: 17145810
    16. Our data suggest that Mel-18 regulates Bmi-1 expression during senescence via down-regulation of c-Myc. PMID: 17151361
    17. These results suggest that Bmi-1 and Mel-18 may have overlapping functions in cancer cell growth. PMID: 17452456
    18. Mel-18 and Bmi-1 may regulate the Akt pathway in breast cancer cells, and that Mel-18 functions as a tumor suppressor by repressing the expression of Bmi-1 and consequently down-regulating Akt activity. PMID: 17545584
    19. Results show that a phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. PMID: 17936708
    20. The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1. PMID: 18706886
    21. Single Nucleotide Polymorphism and down regulation of Mel-18 is associated with prostate cancer. PMID: 19585577
    22. validated occurrence of an unusual TG 3' splice site in intron 1 PMID: 17672918
    23. The mouse counterpart of this gene regulates the expression of Th2 cytokines, and plays a critical role in Th2 cell differentiation and Th-2 dependent immune responses. PMID: 11520462
    24. The mouse counterpart of this gene regulates the expression of various chemokines and chemokine receptors, which may be important for T cell migration and differentiation. PMID: 11750047

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.
  • 数据库链接：

    HGNC: 12929

    OMIM: 600346

    KEGG: hsa:7703

    STRING: 9606.ENSP00000354033

    UniGene: Hs.371617